Bioss Inc.'s IRE1a (Ser726) Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen. The IRE1a (Ser726) Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated was generated using ERN1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis